Promethazine has an elimination 50 percent-lifetime of 10-fourteen hrs, with excretion of metabolites showing from the urine and feces. The sulfoxides of promethazine and N-demethylpromethazine are definitely the predominant metabolites appearing from the urine.Usage of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with Promethazi